Screw position, orientation and the direction of force
The expansion screw should sit on the midpalatal suture, because the force it produces is meant to separate the two halves of the maxilla along that line. A screw placed off-centre expands asymmetrically; a screw tilted to the occlusal plane produces a vertical component that tips the anchor teeth. On a scan the suture can be located from the palatal raphe, and where a CBCT is supplied the suture and the roots are read directly, so the screw is placed on anatomy rather than by eye.
Anteroposterior position is a separate decision. A screw further forward loads the anterior part of the suture more and tends to open the arch more at the front; a screw further back does the reverse. Your prescription sets this, and the design records where the screw centre sits relative to the anchor teeth so that it can be reproduced.
Orientation is set to the occlusal plane by default, which keeps the expansion force horizontal. Where you want the screw angled, for instance to account for a canted palate, the angle is specified and the simulation shows what that angle does to the arm paths through the expansion range.